Chemical Analysis and Risk Assessment of Diethyl Phthalate

May 05, 2022

Phthalates are synthetic compounds that have plenty of applications in different industries. You will find the use of phthalates in the plasticizers of PVC plastics and also in food packaging. Phthalates are also present in personal care products. Diethyl phthalate is a phthalate ester that occurs in the form of a colourless liquid without any significant odor. It has a bitter taste.

Chemicals and Reagents

The list of chemicals includes
1) DMP or Dimethyl phthalate
2) DIBP or di-iso-butyl phthalate
3) Diethyl phthalate
4) DAP or diallyl phthalate
5) DHP or Di heptyl phthalate
6) DNOP or di-n-octyl phthalate

You have to be particular about the quality and grade of these chemicals during acquisition. There is a need to prepare the 3,4,5,6-d4 – DEHP following the standard procedure. The solvents include:
1) Ethyl acetate (> 99.8%)
2) 1,1,2-trichlorotrifluoroethane (>99.9%)
3) n-hexane (>98.0%)
4) cyclohexane (>99.9%) 

Again, the success of the experimentation and procedures depend on the source of acquiring the reagents.

Role of Excipients in Formulation

During any drug formulation process, an excipient is necessary. It is usually a component apart from the active substance or substances present in the medicinal products or becomes a part of the product's manufacturing process.

The chief functions of any excipient include tasks like:
1) Act as a carrier of the active substance or as a primary carrier component. 
2) Imparts specific attributes to the product like stability
3) Biopharmaceutical profile develops from the excipients
4) A patient’s acceptability depends on the nature of the excipients. 

Thus, the role of excipients in any product formulation is appreciable.

Use of diethyl phthalate in cosmetic products

The use of diethyl phthalate in the cosmetic industry is expected. It is now a product that the manufacturers can directly add to the making of the cosmetic product and can use indirectly to make the fragrances.

1) The material is now used as a solvent and vehicle in cosmetic products and fragrances.
2) It can act as a denaturant 
3) The chemical is also a film former. 

Although there have been many speculations regarding the use of chemicals in the cosmetic industry, the manufacturers of cosmetic products ensure to check the toxicity and other factors before using them.

Diethyl Phthalate is a plasticizer.

When you buy plastic toys, do you know that the manufacturing process includes the use of diethyl phthalate? Well, DEP is now acting as a solvent and also as an alcohol denaturant. Thus, it works as a plasticizer in the plastic products and toy manufacturing industry. These phthalates can sometimes dissolve other materials.

Diethyl phthalate Supply & Demand Scenario

There has been significant growth in the urban population. Although the pandemic has hit the financial condition of a broad section of the world population, people are slowly overcoming the issue and now have the spending capability. As the young generation is leaning towards grooming and styling, there has been a higher demand for personal care products and cosmetics. And this has naturally triggered the rapid growth of the global diethyl phthalate market.

The growing population has also caused a surge in demand for modern ways of agricultural cultivation that will boost the yield. As farmers adopt modern-day agricultural techniques, the need for agrochemicals is increasing. And this will have a direct impact on the diethyl phthalate market. As polymers and plastics continue to play a critical role in the industrial segments, the demand for chemicals increases simultaneously.

As you now know about the formulation and, more importantly, the way of working of DEP, you can understand the growing demand for the chemical. The market is about to expand further.

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